Understanding the Disease
A complex inflammatory disease affecting millions worldwide, yet remaining difficult to diagnose.
Sarcoidosis is a systemic inflammatory disease that can affect multiple organs, most commonly the lungs and lymph nodes. It is characterized by the formation of granulomas—organized clusters of immune cells—that may interfere with normal organ function.
The disease presents with a wide range of symptoms and clinical courses, from self-limiting disease to chronic, progressive inflammation. This heterogeneity makes it particularly challenging to diagnose and treat.
The disease is driven by an abnormal immune response, leading to granulomas that may cause permanent organ damage if left untreated or diagnosed too late.
Most commonly affected organ, may cause respiratory symptoms
Can lead to arrhythmias and heart failure
May cause uveitis and vision problems
Various skin manifestations possible
The Challenge
There is no single definitive test for sarcoidosis. Current diagnostic pathways are complex, invasive, and often inconclusive.
Diagnosis typically relies on a combination of clinical assessment, imaging, laboratory tests, and invasive procedures such as biopsies or bronchoalveolar lavage.
Existing blood-based markers lack sufficient sensitivity and specificity, contributing to delayed or missed diagnoses in many patients.
Symptoms can be vague and overlap with other conditions. Progression is unpredictable, making clinical interpretation challenging.
The Impact
For many patients, uncertainty becomes part of everyday life. Late diagnosis can lead to irreversible organ damage and prolonged suffering.
Earlier diagnosis enables earlier intervention, more informed treatment decisions, and the potential to reduce irreversible organ damage and long-term patient suffering.
See How We're Addressing This“Millions of people live with inflammatory diseases that are difficult to diagnose. Symptoms can be vague, progression unpredictable. For many patients, uncertainty becomes part of everyday life.”
Anaxa is developing a blood-based diagnostic approach to address these challenges and support earlier, more reliable diagnosis.